Para poder hacer una busqueda en pubmed primero se tiene que tener en cuenta los booleanos que son AND, OR, NOT  tienes que ingresar a busqueda pubmed luego poner lo que quieres saber, teniendo en cuenta tambien si lo quieres segun los ultimos años, texto completo, humano, espanish o ingles, etc ( puedes escoger lo que deses) :

EJEMPLO:

1- buscador pubmed

2- se coloca lo que quieres buscar, la enfermedad con sus respectivos booleanos

Buscaremos sobre las enfermedades cardiovasculares segun lo que indique

Tiene utilidad la aspirina (aspirin) para la prevención cardiovascular (cardiovascular disease /prevention 

and control) en pacientes con diabetes mellitus (diabetes mellitus) 

Mostrar revisiones de los últimos 5 años en texto completo gratuito

Lo correcto para buscar en pubmed seria:

aspirin effect cardiovascular disease /prevention AND control in patients with diabetes mellitus

y lo colocamos en los ultimos 5 años  

Aspirin effect on the incidence of major adverse cardiovascular events in patients with diabetes mellitus: a systematic review and meta-analysis.

Butalia S1, Leung AA, Ghali WA, Rabi DM.

Author information

Abstract

BACKGROUND:

Aspirin has been recommended for the prevention of major adverse cardiovascular events (MACE, composite of non-fatal myocardial infarction, non-fatal stroke, and cardiovascular death) in diabetic patients without previous cardiovascular disease. However, recent meta-analyses have prompted re-evaluation of this practice. The study objective was to evaluate the relative and absolute benefits and harms of aspirin for the prevention of incident MACE in patients withdiabetes.

METHODS:

We performed a systematic review and meta-analysis on seven studies (N=11,618) reporting on the use of aspirinfor the primary prevention of MACE in patients with diabetes. Two reviewers conducted a systematic search of electronic databases (MEDLINE, EMBASE, the Cochrane Library, and BIOSIS) and hand searched bibliographies and clinical trial registries. Reviewers extracted data in duplicate, evaluated the quality of the trials, and calculated pooled estimates.

RESULTS:

A total of 11,618 participants were included in the analysis. The overall risk ratio (RR) for MACE was 0.91 (95% confidence intervals, CI, 0.82-1.00) with little heterogeneity among trials (I2 0.0%). Secondary outcomes of interest included myocardial infarction (RR, 0.85; 95% CI, 0.66-1.10), stroke (RR, 0.84; 95% CI, 0.64-1.11), cardiovascular death (RR, 0.95; 95% CI, 0.71-1.27), and all-cause mortality (RR, 0.95; 95% CI, 0.85-1.06). There were higher rates of hemorrhagic and gastrointestinal events. In absolute terms, these relative risks indicate that for every 10,000 diabetic patients treated withaspirin, 109 MACE may be prevented at the expense of 19 major bleeding events (with the caveat that the relative risk for the latter is not statistically significant).

CONCLUSIONS:

The studies reviewed suggest that aspirin reduces the risk of MACE in patients with diabetes without cardiovascular disease, while also causing a trend toward higher rates of bleeding and gastrointestinal complications. These findings and our absolute benefit and risk calculations suggest that those with diabetes but without cardiovascular disease lie somewhere between primary and secondary prevention patients on the spectrum of benefit and risk. This underscores the importance of considering individual risk in clinical decision making regarding aspirin in those with diabetes.